| Autor: |
Mohamed A. R. Korashy, Sherif A. Abdel Gawad, Nagiba Y. Hassan, M. AbdelKawy |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Pharmaceutical Sciences, Volume: 58, Article number: e18691, Published: 22 APR 2022 |
| ISSN: |
2175-9790 |
| Popis: |
Two sensitive and selective methods were developed for the simultaneous determination of four commonly used non-steroidal anti-inflammatory drugs (NSAIDs), namely; paracetamol (PCM), diclofenac sodium (DCF), ibuprofen (IBP), and indomethacin (IND) in wastewater effluents. The first method used HPLC for the determination of the studied drugs using a mobile phase consisting of phosphate buffer (pH 3.0) and acetonitrile at a flow rate of 1 mL/min. in gradient elution mode and detection at 220 nm. The separation process was performed on BDS Hypersil Cyano column (250 x 4.6 mm, 5 μm). The second method was a TLC-densitometric one which was performed using n-Hexane: ethyl acetate: acetic acid in the ratio (6:3.5:0.5) as a developing system. The proposed chromatographic methods were successfully applied for the selective determination of the four studied drugs in simulated and real pharmaceutical wastewater samples after their solid-phase extraction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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