Phenotypic Characterization of Juvenile Idiopathic Arthritis in African American Children
| Autor: | Kelly Rouster-Stevens, Lori A. Ponder, Jorge M. Lopez-Benitez, Sheila T. Angeles-Han, Michael P. Epstein, Sampath Prahalad, Kirsten Jenkins, K. Alaine Broadaway, Christina F. Pelajo, Larry B. Vogler, Kelly Rouster Stevens, Karen N. Conneely, Lauren Fitzpatrick |
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| Rok vydání: | 2016 |
| Předmět: |
Male
musculoskeletal diseases Pediatrics medicine.medical_specialty Anti-nuclear antibody Childhood arthritis Immunology Arthritis Peptides Cyclic 03 medical and health sciences 0302 clinical medicine Rheumatology Rheumatoid Factor Internal medicine medicine Humans Immunology and Allergy Rheumatoid factor Registries 030212 general & internal medicine Child skin and connective tissue diseases Autoantibodies 030203 arthritis & rheumatology business.industry medicine.disease Arthritis Juvenile Black or African American Exact test Phenotype Child Preschool Cohort Female Polyarthritis Symptom Assessment business |
| Zdroj: | The Journal of Rheumatology. 43:799-803 |
| ISSN: | 1499-2752 0315-162X |
| Popis: | Objective.Juvenile idiopathic arthritis (JIA) affects children of all races. Prior studies suggest that phenotypic features of JIA in African American (AA) children differ from those of non-Hispanic white (NHW) children. We evaluated the phenotypic differences at presentation between AA and NHW children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and replicated the findings in a JIA cohort from a large center in the southeastern United States.Methods.Children with JIA enrolled in the multicenter CARRA Registry and from Emory University formed the study and replication cohorts. Phenotypic data on non-Hispanic AA children were compared with NHW children with JIA using the chi-square test, Fisher’s exact test, and the Wilcoxon signed-rank test.Results.In all, 4177 NHW and 292 AA JIA cases from the CARRA Registry and 212 NHW and 71 AA cases from Emory were analyzed. AA subjects more often had rheumatoid factor (RF)-positive polyarthritis in both the CARRA (13.4% vs 4.7%, p = 5.3 × 10−7) and the Emory (26.8% vs 6.1%, p = 1.1 × 10−5) cohorts. AA children had positive tests for RF and cyclic citrullinated peptide antibodies (CCP) more frequently, but oligoarticular or early onset antinuclear antibody (ANA)-positive JIA less frequently in both cohorts. AA children were older at onset in both cohorts and this difference persisted after excluding RF-positive polyarthritis in the CARRA Registry (median age 8.5 vs 5.0 yrs, p = 1.4 × 10−8).Conclusion.Compared with NHW children, AA children with JIA are more likely to have RF/CCP-positive polyarthritis, are older at disease onset, and less likely to have oligoarticular or ANA-positive, early-onset JIA, suggesting that the JIA phenotype is different in AA children. |
| Databáze: | OpenAIRE |
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