Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects
| Autor: | Luca Marciani, Carolyn Costigan, Helen L. Parker, Emily Tucker, Mark A. Fox, Penny A. Gowland, Caroline L. Hoad |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Population Gastroenterology Gastric Content 03 medical and health sciences Young Adult 0302 clinical medicine Reference Values Internal medicine medicine Humans Dyspepsia education Meals Aged Test meal Aged 80 and over Meal education.field_of_study medicine.diagnostic_test Gastric emptying Endocrine and Autonomic Systems business.industry Stomach digestive oral and skin physiology Magnetic resonance imaging Middle Aged Postprandial Period Magnetic Resonance Imaging Healthy Volunteers medicine.anatomical_structure Postprandial Gastric Emptying 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female business |
| Zdroj: | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 30(12) |
| ISSN: | 1365-2982 |
| Popis: | BACKGROUND Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs). METHODS The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads [0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods. KEY RESULTS Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes ["late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, bodyweight and sex had measurable effects on gastric function; however, these were small compared to inter-individual variation for most metrics. CONCLUSIONS AND INFERENCES Reference intervals are presented for MRI measurements of gastric function assessed for the mixed liquid/solid NTM. Studies in patients will determine which metrics are of clinical value and also whether the reference intervals presented here offer optimal diagnostic sensitivity and specificity. |
| Databáze: | OpenAIRE |
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