The metabolism of styrene in the rat and the stimulatory effect of phenobarbital
| Autor: | Hatsue Ohtsuji, Masayuki Ikeda |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Phenylglyoxylic acid
Hydrochloride Glucuronates Oxidative phosphorylation Toxicology Styrene Styrenes Lethal Dose 50 chemistry.chemical_compound Glycols Styrene oxide medicine Organic chemistry Animals Biotransformation Pharmacology Hippurates Proadifen Glyoxylates Oxides Metabolism Mandelic acid Stimulation Chemical Rats chemistry Enzyme Induction Phenobarbital Mandelic Acids Female medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 18(2) |
| ISSN: | 0041-008X |
| Popis: | Several known or possible intermediates in styrene metabolism were injected ip in rats and the urinary metabolites were studied. The results together with those from previous studies support the following pathway of styrene metabolism in the rat. Formation of mandelic acid from phenylglyoxylic acid was not detectable. Pretreatment of the animals with phenobarbital enhanced selectively the metabolism of styrene to styrene oxide. Administration of 2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride (SKF 525-A) depressed the metabolism of styrene. The LD50 for styrene oxide was about 1 4 of that for styrene, indicating that the metabolism proceeds through the oxidative conversion to a more toxic compound. |
| Databáze: | OpenAIRE |
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