The gut microbiome composition associates with bipolar disorder and illness severity
| Autor: | Robert Hein, Melvin G. McInnis, Christine M. Bassis, Vince B. Young, Marisa Kelly, Vicky E. Ellingrod, Shervin Assari, Stephanie A. Flowers, Simon J. Evans |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine False discovery rate Bipolar Disorder Population Article Feces 03 medical and health sciences 0302 clinical medicine Rating scale RNA Ribosomal 16S Surveys and Questionnaires medicine Humans Longitudinal Studies Microbiome Bipolar disorder education Biological Psychiatry Psychiatric Status Rating Scales Analysis of Variance education.field_of_study Middle Aged medicine.disease Mental health Gastrointestinal Microbiome Gastrointestinal Tract Patient Health Questionnaire Psychiatry and Mental health 030104 developmental biology Regression Analysis Female medicine.symptom Psychology Mania 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 87:23-29 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2016.12.007 |
| Popis: | The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with burden of disease measures. We compared the stool microbiome from individuals with bipolar disorder (n = 115) and control subjects (n = 64) using 16S ribosomal RNA (rRNA) gene sequence analysis. Analysis of molecular variance (AMOVA) revealed global community case-control differences (AMOVA p = 0.047). Operational Taxonomical Unit (OTU) level analysis revealed significantly decreased fractional representation (p < 0.001) of Faecalibacterium after adjustment for age, sex, BMI and false discovery rate (FDR) correction at the p < 0.05 level. Within individuals with bipolar disorder, the fractional representation of Faecalibacterium associated with better self-reported health outcomes based on the Short Form Health Survey (SF12); the Patient Health Questionnaire (PHQ9); the Pittsburg Sleep Quality Index (PSQI); the Generalized Anxiety Disorder scale (GAD7); and the Altman Mania Rating Scale (ASRM), independent of covariates. This study provides the first detailed analysis of the gut microbiome relationships with multiple psychiatric domains from a bipolar population. The data support the hypothesis that targeting the microbiome may be an effective treatment paradigm for bipolar disorder. |
| Databáze: | OpenAIRE |
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