Bone mineral density in children with beta-thalassemia major in Diyarbakir
| Autor: | Orhan Köksal, Murat Söker, Ayfer Gözü Pirinççioğlu, Veysi Akpolat, Kenan Haspolat |
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| Přispěvatelé: | Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Pirinççioğlu, Ayfer Gözü, Akpolat, Veysi, Köksal, Orhan, Haspolat, Yusuf Kenan, Söker, Murat |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Histology Adolescent Turkey Physiology Endocrinology Diabetes and Metabolism Osteoporosis Deferoxamine Beta-thalassemia Absorptiometry Photon Bone Density Internal medicine medicine Vitamin D and neurology Bone mineral density Humans Femur Vitamin D Child Children Bone mineral Lumbar Vertebrae Anthropometry biology business.industry Osteopenia beta-Thalassemia Infant Beta thalassemia medicine.disease Endocrinology Parathyroid Hormone Case-Control Studies Child Preschool Osteocalcin biology.protein Alkaline phosphatase Female business Type I collagen |
| Popis: | Bone mineral status has extensively been investigated in adult thalassemics but less in thalassemic children. This study involves measurements of the bone mineral density (BMD), various demographic and biochemical parameters in 47 thalassemic children and 50 healthy controls with comparable age, sex, socioeconomic and regional distribution. Patients have significantly higher aspartate aminotransferase, alanine aminotransferase, phosphorous, osteocalcin, serum carboxy terminal teleopeptide fragment of type I collagen, intact parathyroid hormone (iPTH) and ferritin levels while they have significantly lower 25-hydroxy vitamin D (25OH-D), alkaline phosphatase and z-scores both at lumbar and femur compared to controls. Patients with high iPTH (30%) had significantly lower z-scores and 25OH-D while larger osteocalcin. We conclude that a significantly lower BMD in beta-thalassemic children compared with their healthy counterparts is a complex process and may partially attributed to their slower physical development, caused by iron overload and chelation therapy which may influence the liver as well as the endocrine tissues. |
| Databáze: | OpenAIRE |
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