Risk factors associated with myocardial infarction in venous thromboembolism patients
| Autor: | C.V. Damaraju, J. Rondeau-Leclaire, Brahim Bookhart, Scott Kaatz, Jeffrey Schein, Patrick Lefebvre, Edith A. Nutescu, Joyce LaMori, François Laliberté |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Vitamin K Population Myocardial Infarction MEDLINE Coronary Artery Disease Cohort Studies Coronary artery disease Risk Factors Internal medicine medicine Humans Longitudinal Studies cardiovascular diseases Myocardial infarction Intensive care medicine education Stroke Antihypertensive Agents Retrospective Studies education.field_of_study Insurance Health business.industry Anticoagulants Retrospective cohort study Venous Thromboembolism General Medicine Middle Aged equipment and supplies medicine.disease Myocardial infarction complications Female business Cohort study |
| Zdroj: | Current Medical Research and Opinion. 30:27-35 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007995.2013.852525 |
| Popis: | Although risk factors for MI have been described in the general population, there is a lack of data on the assessment of risk factors associated with MI in venous thromboembolism (VTE) patients.The purpose of this study was to identify risk factors associated with MI in VTE patients.Health insurance claims between January 2004 and September 2008 from the Ingenix IMPACT database were analyzed. Patients aged ≥18 years were identified as of the date of their first VTE diagnosis with ≥1 year of continuous insurance coverage before the index VTE. The risk of MI for VTE patients with 1, 2, and ≥3 major risk factors as identified by published guidelines was calculated. Multivariate Cox proportional hazard models were conducted to identify the most predictive risk factors associated with MI.A total of 177,885 VTE patients were identified; 4412 (2.5%) developed an MI during a mean follow-up period of 1.3 years. Previous MI, age (≥65 years), and coronary artery disease were the most predictive risk factors of MI with adjusted hazard ratios (HRs; 95% CI) of 5.47 (5.01-5.97), 1.78 (1.66-1.91), and 1.60 (1.48-1.74), respectively. Adjusted HRs (95% CI) for VTE patients with 1, 2, and ≥3 major risk factors relative to no major risk factor were 2.34 (1.94-2.81), 3.21 (2.67-3.85), and 6.93 (5.85-8.22), respectively.These included possible inaccuracies or omissions in diagnoses, classification bias such as the identification of false-positive MI events, and the likely undercoding of some risk factors such as social issues.Traditional major cardiovascular risk factors are also predictive of MI in VTE patients. Having multiple major risk factors significantly increases the probability of developing MI events in VTE patients. |
| Databáze: | OpenAIRE |
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