Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis
Autor: | Yongjun Luo, Chao Tan, Jia-Lin Wu, Yu Chen, Yun-Peng Hou, Rui Guo |
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Rok vydání: | 2019 |
Předmět: |
Male
Scoring system Future studies Prevalence Review 030204 cardiovascular system & hematology Altitude Sickness 03 medical and health sciences 0302 clinical medicine Sex Factors Sex differences Medicine Humans Risk factor Prospective cohort study Pathological lcsh:R5-920 Acute mountain sickness lcsh:Military Science business.industry lcsh:U Altitude 030229 sport sciences General Medicine Publication bias Risk factors Meta-analysis Acute Disease Female lcsh:Medicine (General) business Demography |
Zdroj: | Military Medical Research Military Medical Research, Vol 6, Iss 1, Pp 1-12 (2019) |
ISSN: | 2054-9369 |
Popis: | Background When lowlanders rapidly ascend to altitudes > 2500 m, they may develop acute mountain sickness (AMS). The individual susceptibility, ascending velocity, time spent at altitude, activity levels and altitude reached are considered risk factors for AMS. However, it is not clear whether sex is a risk factor. The results have been inconclusive. We conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring System. Methods Systematic searches were performed in August 2019 in EMBASE, PubMed, and Web of Science for prospective studies with AMS data for men and women. The titles and abstracts were independently checked in the primary screening step, and the selected full-text articles were independently assessed in the secondary screening step by the two authors (YPH and JLW) based on pre-defined inclusion criteria. The meta-analysis was performed using by the STATA 14.1 software program. A random-effects model was employed. Results Eighteen eligible prospective studies were included. A total of 7669 participants (2639 [34.4%] women) were tested. The results showed that there was a statistically significant higher prevalence rate of AMS in women than in men (RR = 1.24, 95%CI 1.09–1.41), regardless of age or race. Howerver, the heterogeneity was significant in the analysis (Tau2 = 0.0403, Chi2 = 50.15, df = 17; I2 = 66.1%, P = 0.000), it was main caused by different numbers of subjects among the studies (coefficient = − 2.17, P = 0.049). Besides, the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger’s test (bias coefficient = 1.48, P = 0.052) and Begg’s test (P = 0.130). Conclusions According to this study, the statistically significant finding emerging from this study was that women have a higher prevalence of AMS. However, the authors could not exclude studies where patients were on acetazolamide. Our analysis provided a direction for future studies of the relationship of sex and the risk of AMS, such as the pathological mechanism and prevention research. |
Databáze: | OpenAIRE |
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