Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis

Autor:	Christian Borch Jacobsen, Frederik Diness, Morten Meldal, Daniel S. Nielsen
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Chemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element Peptide Cobalt Combinatorial chemistry Adduct Lewis acid catalysis Amino acid
Zdroj:	The Journal of Organic Chemistry. 84:6940-6945
ISSN:	1520-6904 0022-3263
Popis:	Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hetero Diels-Alder adducts. A rational for the observed enantioselectivity and conversion rate supported by computational calculations is provided.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a6b41006957562b18cccef3e198da4 https://doi.org/10.1021/acs.joc.9b00732 Zobrazit plný text záznamu