Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
| Autor: | Rei Otsu, Yoshiaki Taniyama, Ryuichi Morishita, Masaaki Iwabayashi, Fumihiro Sanada, Jun Muratsu, Hiromi Rakugi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Science Adipose tissue Inflammation Type 2 diabetes Diet High-Fat Article 03 medical and health sciences Insulin resistance Internal medicine medicine Animals Humans Insulin Obesity Glucose tolerance test Multidisciplinary biology medicine.diagnostic_test Hepatocyte Growth Factor business.industry Body Weight medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology Adipose Tissue biology.protein Medicine Hepatocyte growth factor Inflammation Mediators Insulin Resistance Antibody medicine.symptom business medicine.drug |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-00199-4 |
| Popis: | Obesity and its associated chronic inflammation in adipose tissue initiate insulin resistance, which is related to several pathologies including hypertension and atherosclerosis. Previous reports demonstrated that circulating hepatocyte growth factor (HGF) level was associated with obesity and type 2 diabetes. However, its precise role in obesity and related-pathology is unclear. In this experiment, cardiac-specific over-expression of human HGF in mice (HGF-Tg mice) which showed 4–5 times higher serum HGF levels than wild-type mice were used. While body weight in wild-type mice fed with high fat diet (HFD) for 14 weeks was significantly increased accompanied with insulin resistance, HGF-Tg mice prevented body weight gain and insulin resistance. The accumulation of macrophages and elevated levels of inflammatory mediators in adipose tissue were significantly inhibited in HGF-Tg mice as compared to wild-type mice. The HFD-induced obesity in wild-type mice treated with HGF-neutralizing antibody showed an exacerbated response to the glucose tolerance test. These gain-of-function and loss-of-function studies demonstrated that the elevated HGF level induced by HFD have protective role against obesity and insulin resistance. |
| Databáze: | OpenAIRE |
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