Prevalence of Seasonal Influenza Vaccination in Chronic Obstructive Pulmonary Disease (COPD) Patients in the Balearic Islands (Spain) and Its Effect on COPD Exacerbations: A Population-Based Retrospective Cohort Study
| Autor: | Miguel Román-Rodríguez, Job F M van Boven, Laura Ruiz Azcona, Montserrat Llort Bove, Miguel Santibáñez Margüello |
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| Přispěvatelé: | Universidad de Cantabria, Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET) |
| Rok vydání: | 2020 |
| Předmět: |
Male
Health Toxicology and Mutagenesis humanos primary prevention lcsh:Medicine Logistic regression Cohort Studies Pulmonary Disease Chronic Obstructive 0302 clinical medicine Prevalence 030212 general & internal medicine estudios de cohortes COPD education.field_of_study prevalencia Vaccination influenza vaccination COPD exacerbations Disease Progression Female Seasons Cohort study medicine.medical_specialty Population Article chronic obstructive pulmonary disease vacunación 03 medical and health sciences progresión de la enfermedad Internal medicine Statistical significance Influenza Human medicine Humans education Retrospective Studies Asthma business.industry estudios retrospectivos lcsh:R Public Health Environmental and Occupational Health copd Retrospective cohort study medicine.disease estaciones (meteorología) respiratory tract diseases 030228 respiratory system Spain business |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 4027, p 4027 (2020) Int. J. Environ. Res. Public Health 2020, 17(11), 4027 UCrea Repositorio Abierto de la Universidad de Cantabria instname International Journal of Environmental Research and Public Health, 17(11):4027, 1-12. MDPI AG International Journal of Environmental Research and Public Health Volume 17 Issue 11 |
| ISSN: | 1660-4601 1661-7827 |
| DOI: | 10.3390/ijerph17114027 |
| Popis: | To determine the prevalence of influenza vaccination in chronic obstructive pulmonary disease (COPD) patients and its effect on COPD exacerbations, we conducted a retrospective population-based cohort study analyzing real-life data. We included all registered COPD patients &ge 40 years old using respiratory medication during the study period (2012&ndash 2013). Influenza vaccination during the 2012/2013 campaign was the parameter studied. Moderate and severe exacerbations during 2013 were the dependent outcome variables. Logistic regression adjusting for age, gender, concomitant asthma diagnosis, COPD severity, smoking status, number of moderate and severe exacerbations the previous year, and comorbidities was performed, and 59.6% of the patients received seasonal influenza vaccination. The percentage of patients with exacerbations was higher among those vaccinated. Influenza vaccination had a statistically significantly negative (non-protective) crude effect favoring the risk of severe exacerbations: OR: 1.20 (95% CI 1.05&ndash 1.37). This association diminished and lost statistical significance after adjustment: aOR: 0.93 (95% CI 0.74&ndash 1.18). The protective effect in the analysis restricted to the epidemic period was not significant: aOR: 0.82 (95% CI 0.58&ndash 1.16). We concluded that prevalence of influenza vaccination was suboptimal. In contrast with most of the available evidence, our results did not support a protective effect of influenza vaccination on the risk of admission for COPD exacerbation. |
| Databáze: | OpenAIRE |
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