An Organic Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients with Acute Coronary Syndrome: A Randomized Crossover Trial
| Autor: | Alessandro Casini, Gian Franco Gensini, Francesco Sofi, Claudia Fiorillo, Stefano Benedettelli, Elena Rafanelli, Anne Whittaker, Maria Luisa Eliana Luisi, Matteo Becatti, Rosanna Abbate |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_treatment medicine.disease_cause Risk profile Gastroenterology Random Allocation Risk Factors Medicine acute coronary syndrome conventional wheat diet khorasan wheat secondary prevention Triticum Secondary prevention Cross-Over Studies Nutrition and Dietetics food and beverages Bread Middle Aged Lipids Female Food Organic lcsh:Nutrition. Foods and food supply medicine.medical_specialty Acute coronary syndrome Khorasan wheat food.ingredient lcsh:TX341-641 Article food Double-Blind Method Species Specificity Internal medicine Humans In patient Aged Inflammation business.industry Insulin medicine.disease Crossover study Biotechnology Oxidative Stress Edible Grain business Biomarkers Oxidative stress Food Science |
| Zdroj: | Nutrients Volume 7 Issue 5 Pages 3401-3415 Nutrients, Vol 7, Iss 5, Pp 3401-3415 (2015) |
| ISSN: | 2072-6643 |
| Popis: | Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects. The aim of this study was to examine whether a replacement diet, thereby substituting all other cereal grains, with products made with organic khorasan wheat could provide additive protective effects in reducing lipid, oxidative and inflammatory risk factors, in patients with Acute Coronary Syndromes (ACS) in comparison to a similar replacement diet using products made from organic modern wheat. A randomized double-blinded crossover trial with two intervention phases was conducted on 22 ACS patients (9 F 13 M). The patients were assigned to consume products (bread, pasta, biscuits and crackers) made either from organic semi-whole khorasan wheat or organic semi-whole control wheat for eight weeks in a random order. On average, patients ingested 62.0 g dry weight (DW) day−1 khorasan or control semolina and 140.5 g DW day−1 khorasan or control flour, respectively. An eight-week washout period was implemented between the respective interventions. Blood analyses were performed both at the beginning and end of each intervention phase thereby permitting a comparison of both the khorasan and control intervention phases, respectively, on circulatory risk factors for the same patient. Consumption of products made with khorasan wheat resulted in a significant amelioration in total cholesterol (−6.8%), low-density lipoprotein cholesterol (LDL-C) (−8.1%) glucose (−8%) and insulin (−24.6%) from baseline levels, independently of age, sex, traditional risk factors, medication and diet quality. Moreover, there was a significant reduction in reactive oxygen species (ROS), lipoperoxidation of circulating monocytes and lymphocytes, as well as in the levels of Tumor Necrosis Factor-alpha. No significant differences from baseline in the same patients were observed after the conventional control wheat intervention phase. The present results suggest that a replacement diet with cereal products made from organic khorasan wheat provides additional protection in patients with ACS. Circulating cardiovascular risk factors, including lipid parameters, and markers of both oxidative stress and inflammatory status, were reduced, irrespective of the number and combination of medicinal therapies with proven efficacy in secondary prevention. |
| Databáze: | OpenAIRE |
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