Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

Autor: Lidia Ángeles Daimiel-Ruiz, Ismael Alvarez-Alvarez, Emilio Ortega Martinez de Victoria, Rocío Zamanillo Campos, Jessica Pérez López, Jorge Romeo-Ollora, Alba Marcos-Delgado, Vicente Martin, Jose Lopez-Miranda, Xavier Pintó Sala, Ramon Sagarra Àlamo, Miguel A. Rubio, ROBERTO ELOSUA, Cristina Razquin, Itziar Salaverría Lete, Cristina Botella, Josep Basora, Sebastian Mas, Mònica Bulló, Álvaro Hernáez, Xavier Capó Fiol, Rosa Casas, Helmut Schroder, José D. Torres Peña, MAIRA BES-RASTROLLO, Monica Domenech, Joan Salvador Vila-Domènech, Christopher Papandreou, Juan José Cabré Vila, Miguel Ruiz-Canela, Manuela Abbate, Manuel Moñino, Jesús Francisco García-Gavilán, Lucía Camacho-Barcia, Paula Carrasco, Alejandro Oncina Canovas, Julia Warnberg, Mario Gutiérrez-Bedmar, Carmen Sayon-Orea, Laura Forcano Gamazo, Iñaki Zorrilla, Alicia Lopez Maldonado, Mercè López Grau, Ana Maria Ruiz-Leon, Cristina Bouzas Velasco, Emili Corbella, Aina M Yañez, Silvia Canudas, Miguel Camafort-Babkowski, FERNANDO FERNANDEZ-ARANDA, José V Sorlí, Laura M Compañ Gabucio, Francisco J Tinahones, ALICIA JULIBERT, Arne Astrup, Laura Torres-Collado, Antoni Colom Fernández, David Benaiges, Jesus Iturralde iriso, Pilar Buil-Cosiales, Olga Castañer Niño, Xavier Corbella, Ana Barabash, Jordi Salas-Salvadó, Miguel-Angel Muñoz, NANCY BABIO SÁNCHEZ, Dora Romaguera, Anna Boronat, Rafel M. Prieto, Pablo Ignacio Hernandez Rivas, Domingo Orozco-Beltran, Gaspar Mestres, GRACIA MARIA QUINTANA-NAVARRO, M. Dolores Zomeño, José Carlos Fernández García, Lucas Tojal Sierra, Iván Abellán Cano, Josep Vidal, Joan Sabate, Inmaculada Bautista-Castaño, Ernest Vinyoles, Sandra González Palacios, Almudena Sanchez Villegas, Susana Gonzalez Torrente, Albert Salas-Huetos, Aurora Bueno Cavanillas, M Rosa Bernal Lopez, Macarena Torrego-Ellacuría, Nuria Estañ Capell, Mariam De la Poza, Jaume Marrugat, Guillermo Sáez, Jesus Vioque, Blanca Riquelme Gallego, Aida Cuenca Royo, Laura Gallardo Alfaro
Přispěvatelé: Fundación Patrimonio Comunal Olivarero, istachios Growers and Almond Board of California
Rok vydání: 2018
Předmět:
Zdroj: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
ISSN: 1464-3685
0300-5771
DOI: 10.1093/ije/dyy225
Popis: The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin olive oil (EVOO) or nuts, reduced cardiovascular disease (CVD). PREDIMED showed a 30% relative reduction in the composite cardiovascular primary endpoint (stroke, myocardial infarction or cardiovascular death).2,,3 However, the PREDIMED trial tested only the composition of the diet, but did not test other lifestyle interventions (i.e. energy reduction, increased physical activity (PA) and behavioural modification) frequently applied in the context of the current unprecedented obesity pandemic.4,,5 With the exception of the null results of the Look-AHEAD trial,6 and the successful results of the EXERDIET-HTA study that found improvements in blood pressure, cardio-respiratory fitness and body composition (though they encouraged adherence to an hypocaloric DASH diet, instead of a Mediterranean diet),7 lifestyle interventions including such components have never been tested in long-term randomized trials using hard cardiovascular events as endpoints.
Databáze: OpenAIRE