Docosahexaenoic acid biostatus is associated with event-related functional connectivity in cortical attention networks of typically developing children
| Autor: | Ronald J. Jandacek, Daniel M. Almeida, Wade Weber, Robert K. McNamara |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male genetic structures Docosahexaenoic Acids Medicine (miscellaneous) Gyrus Cinguli 03 medical and health sciences Typically developing 0302 clinical medicine Child Development Continuous performance task Parietal Lobe medicine Image Processing Computer-Assisted Reaction Time Humans Attention Omega 3 fatty acid Child Anterior cingulate cortex Cerebral Cortex Nutrition and Dietetics Median split medicine.diagnostic_test General Neuroscience Functional connectivity food and beverages General Medicine Magnetic Resonance Imaging 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies Docosahexaenoic acid lipids (amino acids peptides and proteins) Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nutritional neuroscience. 20(4) |
| ISSN: | 1476-8305 |
| Popis: | Although extant preclinical evidence suggests that the long-chain omega-3 fatty acid docosahexaenoic acid (DHA) is important for neurodevelopment, little is known about its role in human cortical structural and functional maturation. In the present cross-sectional study, we investigated the relationship between DHA biostatus and functional connectivity in cortical attention networks of typically developing children.Male children (aged 8-10 years, n = 36) were divided into 'low-DHA' (n = 18) and 'high-DHA' (n = 18) biostatus groups by a median split of erythrocyte DHA levels. Event-related functional connectivity during the performance of a sustained attention task (identical pairs continuous performance task (CPT-IP)) was conducted using functional magnetic resonance imaging. A voxelwise approach used the anterior cingulate cortex (ACC) as the seed-region.Erythrocyte DHA composition in the low-DHA group (2.6 ± 0.9%) was significantly lower than the high-DHA group (4.1 ± 1.1%, P ≤ 0.0001). Fish intake frequency was greater in the high-DHA group (P = 0.003) and was positively correlated with DHA levels among all subjects. The low-DHA group exhibited reduced functional connectivity between the ACC and the ventrolateral prefrontal cortex, insula, precuneus, superior parietal lobule, middle occipital gyrus, inferior temporal gyrus, and lingual gyrus compared with the high-DHA group (P 0.05; corrected). The low-DHA group did not exhibit greater ACC functional connectivity with any region compared with the high-DHA group. On the CPT-IP task, the low-DHA group had slower reaction time (P = 0.03) which was inversely correlated with erythrocyte DHA among all subjects.These data suggest that low-DHA biostatus is associated with reduced event-related functional connectivity in cortical attention networks of typically developing children. |
| Databáze: | OpenAIRE |
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