Metformin use and health care utilization in patients with coexisting chronic obstructive pulmonary disease and diabetes mellitus
| Autor: | Wei Zhang, Victor J. Cardenas, Yong Fang Kuo, Gulshan Sharma, Raju Bishwakarma, Yu Li Lin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Time Factors Databases Factual Health Status Comorbidity Systemic inflammation Pulmonary Disease Chronic Obstructive Patient Admission 0302 clinical medicine ER visits Health care Odds Ratio Hospital Costs Original Research Aged 80 and over COPD diabetes General Medicine Metformin 3. Good health Treatment Outcome Health Resources Female medicine.symptom Emergency Service Hospital hospitalization medicine.drug medicine.medical_specialty International Journal of Chronic Obstructive Pulmonary Disease Medicare Drug Costs 03 medical and health sciences Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Hypoglycemic Agents Medical prescription Aged Retrospective Studies Chi-Square Distribution business.industry Odds ratio medicine.disease United States Confidence interval respiratory tract diseases 030104 developmental biology 030228 respiratory system business Administrative Claims Healthcare |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Raju Bishwakarma,1 Wei Zhang,1 Yu-Li Lin,2 Yong-Fang Kuo,2,3 Victor J Cardenas,1 Gulshan Sharma1,3 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, 2Office of Biostatistics, 3Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, USA Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent systemic inflammation. Anti-inflammatory therapies have been shown to decrease acute exacerbations of COPD. The antidiabetic medication metformin decreases oxidative stress and inflammation and may benefit patients with COPD. We aimed at investigating the effect of metformin on health care utilizations in patients with coexisting COPD and diabetes mellitus (DM). Methods: We studied 5% Medicare beneficiaries with coexisting COPD and DM prescribed metformin or other antidiabetics during the period 2007–2010. The primary outcome was COPD-specific emergency room (ER) visits and hospitalizations; the secondary outcome was all-cause ER visits and hospitalizations over the 2-year follow-up after the index antidiabetic prescription. The effects of metformin were examined by COPD complexity and compared with the effects of other antidiabetic medications. Results: Among 11,260 patients, 3,193 were metformin users and 8,067 were nonusers. Metformin users were younger, were less sick, were less likely to be on oxygen, and had fewer hospitalizations in the prior year compared with the nonusers. Over a 2-year period, metformin users had lower COPD-specific and all-cause ER visits and hospitalizations (7.11% vs 9.61%, p |
| Databáze: | OpenAIRE |
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