Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease
| Autor: | Luiz Gustavo de Sousa, Dimitrius Leonardo Pitol, Adalberto Luiz Rosa, Ana Cláudia Rossi, Marcio Mateus Beloti, Karina Fittipaldi Bombonato-Prado, Selma Siéssere, Paula Katherine Vargas-Sanchez |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Osteoporosis Green tea extract Epigallocatechin gallate Bone resorption Antioxidants Catechin Pathology and Forensic Medicine Bone remodeling chemistry.chemical_compound Bone Density Internal medicine medicine Animals Femur Rats Wistar Molecular Biology Dental alveolus Periodontal Diseases business.industry Plant Extracts Cell Biology Original Articles medicine.disease Rats Endocrinology chemistry Ovariectomized rat Female business |
| Zdroj: | Int J Exp Pathol |
| Popis: | Periodontal disease and osteoporosis are characterized by bone resorption, and researchers have shown an association between these two diseases through increasing loss of systemic bone mass and triggering alveolar bone loss. Green tea is a common and easily accessible beverage, and evidences show that flavonoid epigallocatechin gallate (EGCG) could decrease bone loss in pathologies such as osteoporosis and periodontal disease. In order to verify its possible effects and apply them in the treatment and prevention of these diseases, this investigation aimed to evaluate the influence of green tea extract (GTE) on bone metabolism of ovariectomized rats after experimental periodontal disease (EPD) by histological, morphological and microtomographic parameters. Wistar female rats were divided into Sham, Sham + EPD, Sham + EPD + GTE, OVX, OVX + EPD and OVX + EPD + GTE groups. Immediately after surgery, gavage administration of 50 mg/kg of green tea extract (GTE) was performed for 60 days, with subsequent induction of periodontal disease by ligature 15 days before euthanasia. Mandible and femur samples were collected for histological, morphometric and microtomographic analysis. The results were analysed by means of statistical software with significance set at 5%. Histological and morphometric analysis showed a significant decrease in alveolar and femoral trabecular bone loss in groups that received GTE. Microtomographic results showed that trabecular thickness and bone surface density values in alveolar bone interradicular septum of the OVX + EPD + GTE groups were similar to the Sham group. The results obtained suggest that green tea extract may improve bone metabolism in osteoporotic rats with periodontal disease. |
| Databáze: | OpenAIRE |
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