Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
| Autor: | Rohit Reja, Roger Caothien, Ying-Jiun Chen, Benjamin Haley, Zora Modrusan, Subhra Chaudhuri, Meng He, Shari Lau, Merone Roose-Girma, Jeffrey Eastham-Anderson, Anwesha Dey, Mira S. Chaurushiya, Vishva M. Dixit, Sarah K. Kummerfeld, Debra L. Dugger, Joshua D. Webster, Kim Newton |
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| Rok vydání: | 2019 |
| Předmět: |
Mesothelioma
Uveal Neoplasms 0301 basic medicine Carcinogenesis Ubiquitin-Protein Ligases Apoptosis Biology medicine.disease_cause Histones Mice 03 medical and health sciences 0302 clinical medicine Germline mutation medicine Animals Humans MCL1 Gene Knock-In Techniques Melanoma Germ-Line Mutation Polycomb Repressive Complex 1 BAP1 Mutation Multidisciplinary Tumor Suppressor Proteins Intrinsic apoptosis Ubiquitination Microphthalmia-associated transcription factor Mice Mutant Strains Cell biology Ubiquitin ligase Gene Expression Regulation Neoplastic Editorial Commentary 030104 developmental biology Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis biology.protein Melanocytes Myeloid Cell Leukemia Sequence 1 Protein Ubiquitin Thiolesterase |
| Zdroj: | Translational Cancer Research |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aav4902 |
| Popis: | Tissue specificity of tumor suppression It is well known that the loss of tumor suppressor genes leads to a limited subset of cancers in specific tissues. But why just those tissues? He et al. found a relatively simple explanation for how this tissue selectivity works for the tumor suppressor BAP1 using a mouse model of BAP1-induced cancer. In most cells, loss of BAP1 caused cell death or apoptosis. But in the tissues that formed tumors, differences in the regulation of genes with antiapoptotic effects allowed the cells to survive, even though BAP1 was lost. At least for this one tumor suppressor, its inactivation would normally cause a cell to die; however, this mechanism is absent in a subset of tissues, allowing the cells to proliferate and cause a tumor. Science , this issue p. 283 |
| Databáze: | OpenAIRE |
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