Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: a double blinded crossover study
| Autor: | Thiago José Dionísio, Paulo Zupelari-Gonçalves, Daniel Thomas Brozoski, Elza Araujo Torres, Luis Fernando Simoneti, Fac Faria, Giovana Maria Weckwerth, Jrp Lauris, Adriana Maria Calvo, Carlos Ferreira dos Santos |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Molar Naproxen medicine.medical_specialty Adolescent Visual analogue scale Trismus law.invention Esomeprazole Young Adult 03 medical and health sciences COMPLICAÇÕES PÓS-OPERATÓRIAS 0302 clinical medicine Pharmacotherapy Double-Blind Method Randomized controlled trial law Humans Pain Management Medicine General Dentistry Inflammation Pain Postoperative Cross-Over Studies business.industry Research Anti-Inflammatory Agents Non-Steroidal Proton Pump Inhibitors CIENCIAS MÉDICAS [UNESCO] Crossover study Surgery Treatment Outcome Otorhinolaryngology 030220 oncology & carcinogenesis Anesthesia UNESCO::CIENCIAS MÉDICAS Tooth Extraction Drug Therapy Combination Female Molar Third Oral Surgery medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Weckwerth, Giovana M. ; Simoneti, Luis F. ; Zupelari Gonçalves, Paulo ; Calvo, Adriana M. ; Brozoski, Daniel T. ; Dionísio, Thiago José ; Torres, Elza A. ; Lauris, José Roberto Pereira ; Faria, Flávio Augusto C. ; Santos, Carlos F.. Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 1 2017: 14 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Medicina Oral, Patología Oral y Cirugía Bucal |
| Popis: | Background Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. Material and Methods Parameters were analyzed: self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling. Results Female volunteers reported significantly more postoperative pain at 1, 1.5, 2, 3 and 4hrs after surgery while also taking their first rescue medication at a time significantly earlier when consuming NE when compared to naproxen (3.7hrs and 6.7hrs). Conversely, no differences were found between each drug group in males. Conclusions In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE. Key words:Oral surgery, third molar, pain, naproxen, esomeprazole, NSAIDs. |
| Databáze: | OpenAIRE |
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