Two symmetrical unsaturated acids isolated from Viscum album
| Autor: | Wen Gao, Huirui Guan, Meng Lei, Liang Cheng, Pei-Ming Yang, Zheng-Liang Sun, Yahui Wei, Jia-Kun Dai, Duo Cao, Li-Qing Wang, Xiao-Min Han |
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| Rok vydání: | 2019 |
| Předmět: |
Xanthine Oxidase
Antioxidant Viscum album DPPH medicine.medical_treatment 01 natural sciences Medicinal chemistry Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Picrates Drug Discovery medicine Xanthine oxidase IC50 Molecular Structure biology Acetylene Plant Extracts 010405 organic chemistry Biphenyl Compounds General Medicine biology.organism_classification 0104 chemical sciences Plant Leaves Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Conjugate |
| Zdroj: | Chinese Journal of Natural Medicines. 17:145-148 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(19)30016-0 |
| Popis: | In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L-1, and the SC50 of 4.34 and 8.22 μmol·L-1, respectively. |
| Databáze: | OpenAIRE |
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