Mutation in Bovine β-Carotene Oxygenase 2 Affects Milk Color
| Autor: | Elizabeth Marie Beattie, P. E. Oxley, A. M. Stanfield, Alex Ankersmit-Udy, Natalie Louise Thomas, Alayna Katie Burrett, J. L. Barnett, A. H. K. MacGibbon, Russell G. Snell, H. E. Ward, John F. Pearson, Y. van der Does, Klaus Lehnert, Sarah D. Berry, Stephen R. Davis, Richard J. Spelman, M. Biswas |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Oxygenase Genotype DNA Mutational Analysis Quantitative Trait Loci Regulator Color Biology Quantitative trait locus Polymorphism Single Nucleotide Notes Genetic variation Genetics medicine Animals Amino Acid Sequence Gene Crosses Genetic chemistry.chemical_classification Base Sequence medicine.disease beta Carotene Chromosomes Mammalian Vitamin A deficiency Enzyme Milk Biochemistry chemistry Mutation Oxygenases Cattle Female |
| Popis: | β-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk β-carotene and subsequently identified a premature stop codon in bovine β-carotene oxygenase 2 (BCO2), which also affects serum β-carotene content. The BCO2 enzyme is thereby identified as a key regulator of β-carotene metabolism. |
| Databáze: | OpenAIRE |
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