Updated Insights on EGFR Signaling Pathways in Glioma
| Autor: | Ani-Simona Sevastre, Stefania-Carina Baloi, Suzana Danoiu, Alexandru Oprita, Georgiana-Adeline Staicu, Oana Alexandru, Daniela Elise Tache, Elena Simona Micu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
EGFR pathways Review Catalysis lcsh:Chemistry Inorganic Chemistry Pathogenesis Glioma medicine Temozolomide Humans Epidermal growth factor receptor Physical and Theoretical Chemistry Receptor lcsh:QH301-705.5 Molecular Biology Antineoplastic Agents Alkylating Spectroscopy clinical trials biology business.industry Brain Neoplasms Organic Chemistry General Medicine medicine.disease Combined Modality Therapy Computer Science Applications Clinical trial Radiation therapy ErbB Receptors Gene Expression Regulation Neoplastic lcsh:Biology (General) lcsh:QD1-999 Cancer research biology.protein Signal transduction business Glioblastoma medicine.drug Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 587, p 587 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Nowadays, due to recent advances in molecular biology, the pathogenesis of glioblastoma is better understood. For the newly diagnosed, the current standard of care is represented by resection followed by radiotherapy and temozolomide administration, but because median overall survival remains poor, new diagnosis and treatment strategies are needed. Due to the quick progression, even with aggressive multimodal treatment, glioblastoma remains almost incurable. It is known that epidermal growth factor receptor (EGFR) amplification is a characteristic of the classical subtype of glioma. However, targeted therapies against this type of receptor have not yet shown a clear clinical benefit. Many factors contribute to resistance, such as ineffective blood–brain barrier penetration, heterogeneity, mutations, as well as compensatory signaling pathways. A better understanding of the EGFR signaling network, and its interrelations with other pathways, are essential to clarify the mechanisms of resistance and create better therapeutic agents. |
| Databáze: | OpenAIRE |
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