Plasmodium falciparum: Interaction of shikimate analogues with antimalarial drugs
| Autor: | Louisa McRobert, Shende Jiang, Glenn A. McConkey, Andrew M W Stead |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Drug
Proguanil Antiparasitic medicine.drug_class media_common.quotation_subject Plasmodium falciparum Immunology Shikimic Acid Pharmacology Antimalarials medicine Animals Shikimate pathway Drug Interactions Atovaquone media_common biology Triazines General Medicine biology.organism_classification Pyrimethamine Infectious Diseases Drug development Biochemistry Parasitology Naphthoquinones medicine.drug |
| Zdroj: | Experimental Parasitology. 111:178-181 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/j.exppara.2005.07.002 |
| Popis: | The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with the antimalarial drugs pyrimethamine and atovaquone. Combinations of atovaquone with several shikimate analogues exhibited synergistic effects. These findings highlight potential use of shikimate pathway inhibitors in combination therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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