Pain Reduces Sexual Motivation in Female But Not Male Mice
| Autor: | Yitzchak M. Binik, Mengsha Chen, James G. Pfaus, Alison Leja, Tina Niaki, Melissa A. Farmer, Jeffrey S. Mogil, Vanessa Tabry, Melissa Sukosd, Lucas Topham, Leigh C. MacIntyre, Josiane C.S. Mapplebeck, Lindsey Chan, Emily Foxen-Craft |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Apomorphine Libido Analgesic Pregabalin Pain Carrageenan Peptides Cyclic Mice Sexual Behavior Animal Sex Factors Internal medicine medicine Animals Sex organ Mating gamma-Aminobutyric Acid Analgesics Motivation General Neuroscience Zymosan Chronic pain Articles medicine.disease Sexual dysfunction Endocrinology alpha-MSH Dopamine Agonists Female medicine.symptom Psychology medicine.drug |
| Zdroj: | The Journal of Neuroscience. 34:5747-5753 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.5337-13.2014 |
| Popis: | Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido. We find that inflammatory pain reduces sexual motivation, measured via mounting behavior and/or proximity in a paced mating paradigm, in female but not male laboratory mice. Pain was produced by injection of inflammogens zymosan A (0.5 mg/ml) or λ-carrageenan (2%) into genital or nongenital (hind paw, tail, cheek) regions. Sexual behavior was significantly reduced in female mice experiencing pain (in all combinations); male mice similarly treated displayed unimpeded sexual motivation. Pain-induced reductions in female sexual behavior were observed in the absence of sex differences in pain-related behavior, and could be rescued by the analgesic, pregabalin, and the libido-enhancing drugs, apomorphine and melanotan-II. These findings suggest that the well known context sensitivity of the human female libido can be explained by evolutionary rather than sociocultural factors, as female mice can be similarly affected. |
| Databáze: | OpenAIRE |
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