Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression
| Autor: | Raheel Saeed, Sadia Basharat Ali, Khalid Mahmood, Darakhshan Jabeen Haleem |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Serotonin Psychosis medicine.medical_specialty Dopamine Receptor expression Medicine (miscellaneous) Striatum Impulsivity 03 medical and health sciences 0302 clinical medicine Internal medicine Weight Loss medicine Animals RNA Messenger 030109 nutrition & dietetics Nutrition and Dietetics business.industry General Neuroscience Body Weight Tryptophan General Medicine medicine.disease Diet Rats Endocrinology medicine.symptom Raphe nuclei business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Nutritional Neuroscience. 25:1764-1773 |
| ISSN: | 1476-8305 1028-415X |
| DOI: | 10.1080/1028415x.2021.1901046 |
| Popis: | Anorexia Nervosa (AN) is an eating and behavioral disorder characterized with anxiety/depression, hyperactivity, behavioral impulsivity and psychosis. Most of the associated symptoms are related to the deficiency of serotonin (5-hydroxytryptamine: 5-HT) stores. A deficiency of 5-HT can modulate dopamine neurotransmission in the striatum to elicit hyperactivity and psychosis in AN patients. Also, the release and availability of 5-HT are modulated by serotonin-1A (5-HT1A) auto-receptor. The present study investigates the role of striatal metabolism of 5-HT and dopamine in precipitating hyperactivity in the rat model of diet restriction (DR) induced AN. The role of tryptophan (Trp) in influencing the 5-HT metabolism and the mRNA expression of 5-HT1A auto-receptor is also investigated. We find that long-term DR for 38 days reduces body-weight in rats and produces hyperactivity, similar to AN. This hyperactivity is characterized by declined striatal metabolism of both, dopamine and 5-HT. The mRNA expression of 5-HT1A auto-receptor in the raphe nuclei is also decreased. Trp co-treatment improves these deficiencies in monoamine metabolism and alleviates hyperactivity. Interestingly, DR-induced changes in body-weights are not effected by Trp co-treatment. The study suggests that the striatal metabolism of 5-HT and dopamine and mRNA expression of 5-HT1A auto-receptor has an important role in the pathogenesis of AN. The finding suggests that co-use of Trp can prevent precipitation of AN by normalizing 5-HT metabolism. |
| Databáze: | OpenAIRE |
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