Design of Rhenium Compounds in Targeted Anticancer Therapeutics
| Autor: | Veena Vijaykumar, Philippe Collery, Didier Desmaële |
|---|---|
| Přispěvatelé: | Institut Galien Paris-Saclay (IGPS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Société de Coordination de Recherches Thérapeutiques, Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Biodistribution
Luminescence medicine.medical_treatment Drug Evaluation Preclinical Antineoplastic Agents Mitochondrion 010402 general chemistry 01 natural sciences Signaling Pathways Oxidative Stress Markers Targeted therapy [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication Coordination Complexes Drug Discovery medicine cancer [CHIM]Chemical Sciences Humans Doxorubicin Tissue Distribution Cytotoxicity ComputingMilieux_MISCELLANEOUS Pharmacology Clinical Trials as Topic Cell Death 010405 organic chemistry Chemistry Personalized Treatment [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 3. Good health 0104 chemical sciences Oxidative Stress Rhenium Cancer cell Cancer research Signal transduction [CHIM.OTHE]Chemical Sciences/Other Phototoxicity medicine.drug Signal Transduction |
| Zdroj: | Current Pharmaceutical Design Current Pharmaceutical Design, Bentham Science Publishers, 2019, 25, pp.3306-3322. ⟨10.2174/1381612825666190902161400⟩ Current Pharmaceutical Design, Bentham Science Publishers, 2019, 25, ⟨10.2174/1381612825666190902161400⟩ Current Pharmaceutical Design, Bentham Science Publishers, 2019, 25 (31), pp.3306-3322. ⟨10.2174/1381612825666190902161400⟩ |
| ISSN: | 1873-4286 1381-6128 |
| DOI: | 10.2174/1381612825666190902161400⟩ |
| Popis: | Background: Many rhenium (Re) complexes with potential anticancer properties have been synthesized in the recent years with the aim to overcome the clinical limitations of platinum agents. Re(I) tricarbonyl complexes are the most common but Re compounds with higher oxidation states have also been investigated, as well as hetero-metallic complexes and Re-loaded self-assembling devices. Many of these compounds display promising cytotoxic and phototoxic properties against malignant cells but all Re compounds are still at the stage of preclinical studies. Methods: The present review focused on the rhenium based cancer drugs that were in preclinical and clinical trials were examined critically. The detailed targeted interactions and experimental evidences of Re compounds reported by the patentable and non-patentable research findings used to write this review. Results: In the present review, we described the most recent and promising rhenium compounds focusing on their potential mechanism of action including, phototoxicity, DNA binding, mitochondrial effects, oxidative stress regulation or enzyme inhibition. Many ligands have been described that modulating the lipophilicity, the luminescent properties, the cellular uptake, the biodistribution, and the cytotoxicity, the pharmacological and toxicological profile. Conclusion: Re-based anticancer drugs can also be used in targeted therapies by coupling to a variety of biologically relevant targeting molecules. On the other hand, combination with conventional cytotoxic molecules, such as doxorubicin, allowed to take into profit the targeting properties of Re for example toward mitochondria. Through the example of the diseleno-Re complex, we showed that the main target could be the oxidative status, with a down-stream regulation of signaling pathways, and further on selective cell death of cancer cells versus normal cells. |
| Databáze: | OpenAIRE |
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