Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial

Autor: Magda Feres, Fernando Lucas Primo, Morgana Rodrigues Guimarães-Stabili, Emily Bellile, Natalie Ap. Rodrigues Fernandes, Belén Retamal-Valdes, Antonio Claudio Tedesco, Cindy Grace Pérez-Pacheco, Carlos Rossa
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP), University of Michigan School of Public Health, Universidade de Guarulhos - UNG
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Popis: Made available in DSpace on 2021-06-25T10:37:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Objective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results: PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion: We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy. Department of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP) Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP) Department of Chemistry Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao Paulo Biostatistics University of Michigan School of Public Health Department of Periodontology and Oral Implantology Dental Research Division Universidade de Guarulhos - UNG Department of Diagnosis and Surgery School of Dentistry at Araraquara Sao Paulo State University (UNESP) Department of Bioprocess and Biotechnology Faculty of Pharmaceutical Sciences of Araraquara Sao Paulo State University (UNESP)
Databáze: OpenAIRE
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