Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection
| Autor: | Richard I. Morimoto, M G Santoro |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cell Survival
Lactams Macrocyclic Biomedical Engineering Ischemia Bioengineering Hydroxylamine Applied Microbiology and Biotechnology Heat shock protein medicine Benzoquinones Animals Humans Heat shock Heat-Shock Proteins biology Chemistry Amyloidosis Anti-Inflammatory Agents Non-Steroidal Quinones Injury and repair medicine.disease Cytoprotection Cell biology Stress inducible Oxidative Stress Rifabutin Chaperone (protein) Drug Design Immunology biology.protein Molecular Medicine Heat-Shock Response Biotechnology |
| Zdroj: | Nature biotechnology. 16(9) |
| ISSN: | 1087-0156 |
| Popis: | Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response. |
| Databáze: | OpenAIRE |
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