Prognostic Value of 18-Fluorodeoxyglucose-Positron Emission Tomography After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma Undergoing Orthotopic Liver Transplantation
| Autor: | J.L. Navarro, E. Llacer, Ricardo Robles, Laura Frutos, P. Ramirez, Antonio Capel, F Sánchez Bueno, Vasthi Lopez, P.A. Cascales-Campos, L. Saenz-Mateos, P. Muñoz-Ramon, J.A. Pons, Pascual Parrilla, Robinson G. Gonzalez |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular medicine.medical_treatment Standardized uptake value Liver transplantation Multimodal Imaging Necrosis Fluorodeoxyglucose F18 medicine Humans Chemoembolization Therapeutic Survival rate Aged Retrospective Studies Transplantation medicine.diagnostic_test business.industry Liver Neoplasms Retrospective cohort study Middle Aged medicine.disease Prognosis Combined Modality Therapy Liver Transplantation Survival Rate Treatment Outcome Positron emission tomography Hepatocellular carcinoma Positron-Emission Tomography Surgery Female Radiology Hepatectomy Radiopharmaceuticals business Nuclear medicine Tomography X-Ray Computed Vascular Surgical Procedures |
| Zdroj: | Transplantation proceedings. 47(8) |
| ISSN: | 1873-2623 |
| Popis: | Introduction The aim of this study was to analyze the correlation between 18-FDG positron emission tomography (PET)/computed tomography (CT), histological necrosis, and prognosis after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients undergoing orthotopic liver transplantation (OLT). Patients From January 2007 through December 2013, 81 patients with HCC and liver cirrhosis were included in our liver transplantation program. For this study we selected patients who underwent 18-FDG PET/CT pre-TACE and post-TACE. All patients underwent liver transplantation within 8 weeks after PET/CT. Results Twenty patients with a median age of 58 years (range, 46–69 years) underwent an 18-FDG PET/CT before and after TACE. The median Standardized Uptake Value (SUV) before TACE was 3.8 (range, 2.6–8.7), with a median post-TACE SUV of 0% (range, 0–4). Among patients whose post-TACE SUV decreased to 70% necrosis was observed upon study of a hepatectomy sample, with a survival rate of 100% and 80% at 1 and 3 years, respectively. Conclusion In conclusion, performance of an 18-FDG PET/CT before and after TACE with comparison of SUV values among patients with HCC awaiting OLT provided valuable information regarding the effectiveness of TACE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect