Self-assembled peptide nanoparticles with endosome escaping permits for co-drug delivery
| Autor: | Xiaofei Zheng, Zhenkai Zhu, Yingshu Guo, Qiong Li, Zhiyong Wei, Yinhua Hu, Xiuping Cao, Shusheng Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Modern medicine Aptamer media_common.quotation_subject Cell Peptide Antineoplastic Agents 02 engineering and technology Endosomes 01 natural sciences Analytical Chemistry Drug Delivery Systems medicine Humans Doxorubicin media_common chemistry.chemical_classification Drug Carriers Chemistry 010401 analytical chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure Drug delivery Cancer research MCF-7 Cells Nanoparticles Nanocarriers 0210 nano-technology Peptides medicine.drug |
| Zdroj: | Talanta. 221 |
| ISSN: | 1873-3573 |
| Popis: | The diagnosis and treatment of major diseases, especially tumors, was the key to improving the cure rate and survival rate of patients. Therefore, one of the main goals of modern medicine was to develop effective, non-toxic treatments. This paper successfully established dipeptide nanoparticles/clofarabine/aptamer AS1411/influenza hemagglutinin peptide/siRNA/doxorubicin (DNPs/Clolar/AS1411/HA/RNA/DOX) multi-functional nanoparticles for specific delivery, cancer treatment and bioimaging. It was an ideal choice for multi-drug synergy treatment. First, non-toxic DNPs formed by self-assembly of dipeptides with safe and biocompatible effect. Second, from the perspective of the multi-functional nanoparticles for nano-drug tumors imaging monitoring, AS1411 and HA were used as cell permits for enhancing the specificity of cell drug delivery ability and improving the endosomal escape, respectively. Third, the multi-functional nanoparticles with Clolar, siRNA and DOX, three drug synergistic treatments were used to improve the therapeutic effect of tumors. Both cell experiments and vivo experiments demonstrated that the synergistic treatment of the multi-drugs was superior to the effect of single-drug therapy. Thus, the proposed multi-functional nanoparticles have initiated new ideas for these hybrid anticancer drugs based on peptide self-assembled nanocarriers and its widely applications in biomedicine. |
| Databáze: | OpenAIRE |
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