Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes)
| Autor: | Taras Y. Vitak, Nataliya O. Sybirna, Solomon P. Wasser, Eviatar Nevo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Antioxidant Erythrocytes Reishi medicine.medical_treatment Agaricus Glutathione reductase Pharmacology medicine.disease_cause Applied Microbiology and Biotechnology Antioxidants Diabetes Mellitus Experimental Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Superoxides Drug Discovery Botany medicine Animals Hypoglycemic Agents Rats Wistar chemistry.chemical_classification Reactive oxygen species Biological Products Glutathione Peroxidase 030102 biochemistry & molecular biology biology Mycelium Glutathione peroxidase biology.organism_classification Catalase Thiobarbiturates Oxidative Stress chemistry biology.protein Reactive Oxygen Species Oxidative stress |
| Zdroj: | International journal of medicinal mushrooms. 19(8) |
| ISSN: | 1940-4344 |
| Popis: | Excessive glucose concentrations in blood and cells promote the intensification of auto-oxidation. This is one of the mechanisms through which free radicals form in hyperglycemia. As a result of hyperglycemia, oxidative stress develops and lipid peroxidation (LPO) is enhanced. Erythrocytes are particularly susceptible to reactive oxygen species and LPO, which can violate cell functions. This article describes the analysis of the influence of mycelia from the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum on the enzymatic link of the antioxidant system in rat erythrocytes under streptozotocin-induced diabetes mellitus. Oxidative stress was strengthened in red blood cells of diabetic rats, as evidenced by decreased activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, and by increased amounts of thiobarbituric acid-positive products, which are markers of LPO. Administration of A. brasiliensis and G. lucidum submerged cultivated mycelial powder to animals with streptozotocin-induced diabetes restored superoxide dismutase, catalase, and glutathione peroxidase activity and reduced the amounts of thiobarbituric acid-positive products to control values, but did not affect the activity of glutathione reductase. |
| Databáze: | OpenAIRE |
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