Strategies to improve fertilisation rates with assisted conception: a systematic review
| Autor: | Neelam Potdar, Yadava B. Jeve, Jane A. Blower, Tarek A. Gelbaya |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Ovid medline Pregnancy Rate Reproductive Techniques Assisted medicine.medical_treatment Cochrane Library Biology Intracytoplasmic sperm injection Sperm injection 03 medical and health sciences 0302 clinical medicine Qualitative analysis Pregnancy medicine Humans Intensive care medicine Fertilisation Gynecology 030219 obstetrics & reproductive medicine Obstetrics and Gynecology General Medicine 030104 developmental biology Reproductive Medicine Fertilization Female |
| DOI: | 10.6084/m9.figshare.5044543 |
| Popis: | Successful fertilisation is one of the key steps determining success of assisted conception. Various factors including sperm or oocyte pathology and environmental factors have a significant impact on fertilisation rates. This systematic review is aimed to evaluate the existing evidence about factors affecting fertilisation and strategies to improve fertilisation rates. A literature search was performed using Ovid MEDLINE ® (Jan 1950–April 2016), EMBASE (Jan 1950–April 2016), Ovid OLDMEDLINE ®, Pre-MEDLINE (Jan 1950–April 2016) and the Cochrane Library. Relevant key words were used to combine sets of results and a total 243 papers were screened. Only qualitative analysis was performed, as there was major heterogeneity in study design and methodology for quantitative synthesis. Factors affecting fertilisation were divided into sperm- and oocyte-related factors. The methods to improve fertilisation rates were grouped together based on the approach used to improve fertilisation rates. Optimising laboratory condition and procedural effects in techniques is associated with improved fertilisation rates. Various techniques are described to improve fertilisation rates including assisted oocyte activation, physiological intracytoplasmic sperm injection (PICSI) and intracytoplasmic morphologically selected sperm injection (IMSI). This review highlights the promising strategies under research to enhance fertilisation rates. Adequately powered multicentre randomised trials are required to evaluate these techniques before considering clinical application. |
| Databáze: | OpenAIRE |
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