Kainic acid prevents peroxidase labeling of retinal ganglion cell bodies in the rat: A possible gate in retrograde axonal transport
| Autor: | P. Gomez-Ramos, F. Reinoso-Suarez |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Retinal Ganglion Cells Kainic acid Pyrrolidines Axonal Transport Horseradish peroxidase Retinal ganglion Retina chemistry.chemical_compound medicine Animals Horseradish Peroxidase Kainic Acid biology General Neuroscience Glutamate receptor Optic Nerve Rats Inbred Strains Axons eye diseases Rats Cell biology medicine.anatomical_structure Peroxidases nervous system chemistry Biochemistry Retinal ganglion cell biology.protein Axoplasmic transport sense organs Peroxidase |
| Zdroj: | Neuroscience Letters. 35:1-6 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(83)90517-7 |
| Popis: | Kainic acid, a neurotoxic analogue of glutamate, injected into the vitreous body of the eye, interferes with the retrograde transport of the marker enzyme horseradish peroxidase. This intereference is expressed by the absence of detectable peroxidase in the cell bodies of the retinal ganglion cells and by the presence of the marker in the intraretinal portions of the optic axons. These results suggest the hypothesis of the existence of some kind of gate at the proximal portion of the axons which would control the entry of retrogradely moving material into the cell body. |
| Databáze: | OpenAIRE |
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