ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways
| Autor: | Samieh Asadian, Hossein Ahmadpour Yazdi, Nematollah Gheibi, Maryam Navaeian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Peptide Hormones Bioinformatics 03 medical and health sciences 0302 clinical medicine Hypothyroidism Metabolic Diseases Angiopoietin-Like Protein 8 Diabetes mellitus Genetics Medicine Animals Humans Molecular Biology Cell Proliferation business.industry Lipid metabolism General Medicine medicine.disease Obesity Polycystic ovary 030104 developmental biology Angiopoietin-like Proteins 030220 oncology & carcinogenesis Female Metabolic syndrome Signal transduction business Dyslipidemia Hormone Polycystic Ovary Syndrome Signal Transduction |
| Zdroj: | Molecular biology reports. 48(4) |
| ISSN: | 1573-4978 |
| Popis: | A new and atypical member of the ANGPTL family is angiopoietin-like protein 8 (ANGPTL8). This newly discovered hormone is a drug target that can be used to treat diabetes and dyslipidemia. The protein, as a hepatocyte-derived circulating factor, can control the triglyceride level of plasma. ANGPTL8 is significantly associated with inflammation and metabolic syndrome consequences such as obesity, diabetes, hypothyroidism, and PCOS. ANGPTL8 gene has four exons encoding a 22/5 kDa weight of 198 amino acid polypeptides. A highly preserved ANGPTL8 gene among mammals exhibits the essential hormone functions of ANGPTL8. Nevertheless, the physiological function of this hormone in the body is poorly understood. Studies published in PubMed (2008–2020), Google Scholar (2004–2020), and Scopus (2004–2020) databases of clinical trials were reviewed. This analysis is aimed at collecting information on ANGPTL8. The emphasis of this review was on gathering information about the role of ANGPTL8 in the metabolism of glucose and lipids and cell proliferation. It addition to the different roles of ANGPTL8 in diabetes and lipid metabolism, this review emphasized on the protein role in signaling pathways. The study also proposes the signaling pathways that may be considered as a new target for treatment. |
| Databáze: | OpenAIRE |
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