Effect of L-asparaginase on carbohydrate metabolism
| Autor: | Naguib A. Samaan, C. Stratton Hill, Gerald P. Bodey, John P. Whitecar |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Cancer chemotherapy Endocrinology Diabetes and Metabolism medicine.medical_treatment Serum insulin level Serum insulin Adrenal Gland Neoplasms Radioimmunoassay Carbohydrate metabolism L asparaginase Islets of Langerhans Endocrinology Internal medicine medicine Asparaginase Humans Insulin Serum Albumin Glucose tolerance test Leukemia medicine.diagnostic_test business.industry Human growth hormone Fibrinogen Glucose Tolerance Test Middle Aged Child Preschool Growth Hormone Hyperglycemia Carbohydrate Metabolism Female Multiple Myeloma business |
| Zdroj: | Metabolism. 19:581-586 |
| ISSN: | 0026-0495 |
| Popis: | Glucose tolerance tests and simultaneous serum insulin and human growth hormone (HGH) levels were determined in 4 patients undergoing cancer chemotherapy with L-asparaginase. A significant impairment occurred in the glucose tolerance test in two of these patients receiving L-asparaginase. Serum insulin levels decreased significantly in all patients. An additional patient had a very low serum insulin level despite severe hyperglycemia which preceded his death. In all patients HGH remained normal to low. It appears that the hyperglycemia which results from L-asparaginase therapy is due to a decrease in insulin synthesis. |
| Databáze: | OpenAIRE |
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