Incremental increases in glucocorticoid doses may reduce the risk of osmotic demyelination syndrome in a patient with hyponatremia due to central adrenal insufficiency
| Autor: | Kenji Adachi, Keiko Yamagami, Katsunobu Yoshioka, Shunsuke Fujimoto, Mieko Minami, Seiko Yamaguchi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Osmosis genetic structures Central adrenal insufficiency Gastroenterology Risk Factors Internal medicine Internal Medicine medicine Humans Glucocorticoids Hydrocortisone Dose-Response Relationship Drug business.industry nutritional and metabolic diseases General Medicine Syndrome Middle Aged medicine.disease Dose–response relationship Endocrinology General malaise Diabetes insipidus Hyponatremia business Glucocorticoid medicine.drug Adrenal Insufficiency Demyelinating Diseases |
| Zdroj: | Internal medicine (Tokyo, Japan). 51(9) |
| ISSN: | 1349-7235 |
| Popis: | A 50-year-old man was admitted to our hospital because of general malaise. Laboratory tests revealed severe hyponatremia (104 mEq/L), which was attributed to central adrenal insufficiency. To treat presumed central diabetes insipidus (CDI), we administered a small dose of hydrocortisone and gradually increased it to maintenance doses to prevent osmotic demyelination syndrome (ODS). Serum sodium levels did not increase more than 10 mEq/L/day and ODS did not occur. Thereafter, the patient was proven to have CDI. Incremental increases in glucocorticoid dose may reduce the risk of ODS for patients with hyponatremia due to central adrenal insufficiency, especially that complicated by CDI. |
| Databáze: | OpenAIRE |
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