Neuropsychological deficits in adolescent methamphetamine abusers
| Autor: | Linda Chang, Daniel Alicata, Christine C. Cloak, George R. King |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent Amphetamine-Related Disorders Poison control Neuropsychological Tests Article Methamphetamine Executive Function Young Adult chemistry.chemical_compound Cognition Memory medicine Humans Attention Child Psychiatry Amphetamine Pharmacology Cognitive disorder Neurotoxicity Neuropsychology Meth medicine.disease chemistry Case-Control Studies Female Psychology Neurocognitive Psychomotor Performance Clinical psychology medicine.drug |
| Zdroj: | Psychopharmacology. 212:243-249 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-010-1949-x |
| Popis: | Methamphetamine (METH) is a widely abused psychostimulant that is associated with neurotoxicity and neurocognitive impairments in adults. However, the effects of METH use on neurocognitive performance of adolescents are unclear.Fifty-four adolescent METH users and 74 age-matched comparison subjects (ages 12 to 23 years) were evaluated with a battery of neuropsychological tests. The cognitive domains evaluated include psychomotor (Symbol Digit, Trail Making), executive function (Stroop Interference task, Wisconsin Card Sort task), fine-motor speed (Grooved Pegboard), memory (Digit span and Auditory Verbal Learning Task), as well as attention and working memory (California Computerized Assessment package).METH users were slower on the Stroop Interference task than the comparison subjects (F(1,114) = 4.33, p = 0.03). METH subjects also performed worse than controls on the Wechsler Adult Intelligence Scale III/Wechsler Intelligence Scale for Children IV (WAIS/WISC) Matrices task (F(1,114) = 4.37, p = 0.04) and performed significantly worse on the Peg Board task than the comparison subjects for both the dominant (F(1,114) = 7.56, p = 0.01) and non-dominant (F(1,114) = 6.75, p = 0.01). Lastly, length of abstinence was associated with improved performance on the Peg Board test with the dominant had (r = -0.34), as well as the WAIS/WISC Forward Digit Span task (r = 0.38)METH use is associated with impaired executive functions in adolescent users. |
| Databáze: | OpenAIRE |
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