Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene®) and pharmaceutical products frequently used for combined therapy by intravenous administration
| Autor: | Orietta Perilli, Pietro Mazzeo, Sandro Bartolini, Giuseppe Carlucci, Gentile Marco, Roberto Anacardio |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Drug
Ketoprofen media_common.quotation_subject Clinical Biochemistry Lysine Pharmaceutical Science Ketoprofen lysine Pharmacology High-performance liquid chromatography Analytical Chemistry Drug Discovery medicine Chromatography High Pressure Liquid Spectroscopy media_common Antibacterial agent Chromatography Chemistry Anti-Inflammatory Agents Non-Steroidal Hydrogen-Ion Concentration Artrosilene stomatognathic diseases Pharmaceutical Preparations Injections Intravenous Combined therapy Spectrophotometry Ultraviolet medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 32:1235-1241 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(03)00061-x |
| Popis: | Ketoprofen lysine salt (Artrosilene® Fiale) is a non-steroidal anti-inflammatory agent frequently administered by intravenous infusion in association regimen with other drugs, such as steroidal anti-inflammatory, anti-hemorrhagic, anti-spastic, anti-ulcer, and antibacterial drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene® Fiale) and other injectable drugs frequently used in association. Physicochemical properties of ketoprofen lysine salt mixtures with different drugs, including colour, clarity, pH and drug content were observed or measured before and after (up to 5 h) mixing at room temperature and under light protection. Results show that the association of Artrosilene® Fiale with different drugs does not cause, up to 5 h from mixing, any significant variation in the physicochemical parameters mentioned above. In conclusion, the results obtained demonstrated the physicochemical compatibility of ketoprofen lysine salt (Artrosilene® Fiale) with several drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect