Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon
| Autor: | Simone K. Forbes, Selmir Avdic, Allison Abendroth, Emily A. Machala, Barry Slobedman, Brian P. McSharry, David Gottlieb, John Z. Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Human cytomegalovirus
viruses Galectins Immunology Cytomegalovirus Biology Microbiology Mediator Downregulation and upregulation In vivo Transcription (biology) Interferon Virology medicine Humans Galectin virus diseases Interferon-beta medicine.disease Molecular biology In vitro Up-Regulation Insect Science Cytomegalovirus Infections Host-Pathogen Interactions Pathogenesis and Immunity medicine.drug |
| Popis: | Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro , Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|