Comparison Between Ray-Tracing and Full-Wave Simulation for Transcranial Ultrasound Focusing on a Clinical System Using the Transfer Matrix Formalism
| Autor: | Philippe Annic, Yeruham Shapira, Mickael Tanter, Itay Rachmilevitch, Alexandre Houdouin, Jean-François Aubry, Thomas Bancel |
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| Přispěvatelé: | Physique pour la médecine (UMR 8063, U1273), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
clinical system
Insightec Acoustics and Ultrasonics Phased array Acoustics transcranial focusing Phase (waves) 02 engineering and technology aberration correction law.invention 03 medical and health sciences law Hounsfield scale Humans ray-tracing Computer Simulation Electrical and Electronic Engineering Instrumentation Image resolution Ultrasonography 030304 developmental biology Physics 0303 health sciences k-wave toolbox Hydrophone ultrasound business.industry Skull Ultrasound Brain HIFU 021001 nanoscience & nanotechnology numerical modeling Pressure measurement [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] [SDV.IB]Life Sciences [q-bio]/Bioengineering Ray tracing (graphics) Tomography X-Ray Computed 0210 nano-technology business |
| Zdroj: | IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers, 2021, pp.1-1. ⟨10.1109/TUFFC.2021.3063055⟩ |
| ISSN: | 1525-8955 0885-3010 |
| DOI: | 10.1109/tuffc.2021.3063055 |
| Popis: | International audience; Only one High Intensity Focused Ultrasound device has been clinically approved for transcranial brain surgery at the time of writing. The device operates within 650 kHz and 720 kHz and corrects the phase distortions induced by the skull of each patient using a multi-element phased array. Phase correction is estimated adaptively using a proprietary algorithm based on computed-tomography (CT) images of the patient's skull. In this paper, we assess the performance of the phase correction computed by the clinical device and compare it to (i) the correction obtained with a previously validated full-wave simulation algorithm using an open-source pseudo-spectral toolbox and (ii) a hydrophone-based correction performed invasively to measure the aberrations induced by the skull at 650 kHz. For the full-wave simulation, three different mappings between CT Hounsfield units and the longitudinal speed of sound inside the skull were tested. All methods are compared with the exact same setup thanks to transfer matrices acquired with the clinical system for N=5 skulls and T=2 different targets for each skull. We show that the clinical ray-tracing software and the full-wave simulation restore respectively 84±5% and 86±5% of the pressure obtained with hydrophone-based correction for targets located in central brain regions. On the second target (off-center), we also report that the performance of both algorithms degrades when the average incident angles of the acoustic beam at the skull surface increases. When incident angles are higher than 20°, the restored pressure drops below 75% of the pressure restored with hydrophone-based correction. |
| Databáze: | OpenAIRE |
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