Patch testing with purified and oxidized citronellol

Autor:	Johanna Bråred Christensson, Ann-Therese Karlberg, Lina Hagvall, Johanna Rudbäck
Rok vydání:	2020
Předmět:	Adult Male Acyclic Monoterpenes Dermatology Patch testing Terpene 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Linalool medicine Immunology and Allergy Humans 030212 general & internal medicine Allergic contact dermatitis Citronellol Limonene Chromatography Autoxidation Terpenes Patch test Allergens Middle Aged Patch Tests medicine.disease Perfume chemistry Dermatitis Allergic Contact Irritants Female Oxidation-Reduction
Zdroj:	Contact dermatitisREFERENCES. 83(5)
ISSN:	1600-0536
Popis:	BACKGROUND Citronellol is a commonly used fragrance terpene included in fragrance mix II. As with many other fragrance terpenes, citronellol is susceptible to autoxidation. Citronellol hydroperoxides are formed in large amounts and are the only oxidation products identified as sensitizers in oxidized citronellol. AIM To compare frequencies of contact allergy to purified and oxidized citronellol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series, oxidized linalool, and oxidized limonene. METHODS A total of 658 dermatitis patients were patch tested with purified and oxidized citronellol at 2.0%, 4.0%, 6.0%, and 1.0%, 2.0%, 4.0%, 6.0% petrolatum, respectively. The irritant properties of purified and oxidized citronellol were studied before patch testing. RESULTS Few irritant reactions were observed in the pretest. Purified citronellol detected positive reactions in 0.15%-0.31% of patients, while oxidized citronellol detected positive reactions in 0.61%-4.5%. Among patients reacting to oxidized citronellol, 34%-50% showed concomitant reactions to fragrance markers of the baseline series and 75%-91% to oxidized linalool or oxidized limonene. CONCLUSION Oxidized citronellol detects more cases of contact allergy than purified citronellol, and these cases are not all detected using fragrance mix II. Patch testing with oxidized citronellol will add to the tools in the diagnosis of fragrance allergy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d3c5e8ab85272f374a035b25aaa915 https://pubmed.ncbi.nlm.nih.gov/32638395 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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