Longterm experience with oral gold in rheumatoid arthritis and psoriatic arthritis
| Autor: | W. Verdickt, K. Vanschoubroek, J. Dequeker, G. Gevers |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Auranofin Propanols Anti-Inflammatory Agents Arthritis Gastroenterology Arthritis Rheumatoid Psoriatic arthritis Random Allocation Rheumatology Double-Blind Method Internal medicine medicine Organometallic Compounds Humans Psoriasis Prospective Studies Sulfhydryl Compounds Aurothioglucose Clinical Trials as Topic business.industry Gold Therapy General Medicine Middle Aged medicine.disease Long-Term Care Surgery Clinical trial Tolerability Rheumatoid arthritis Patient Compliance Dimercaprol Female Gold business Organogold Compounds medicine.drug |
| Zdroj: | Clinical rheumatology. 3 |
| ISSN: | 0770-3198 |
| Popis: | Oral gold (auranofin) has been used in 31 patients, 20 with active rheumatoid arthritis and 11 with active psoriatic arthritis. In rheumatoid arthritis the oral gold treatment was compared to parenteral gold treatment in a patient blind trial for two years. The psoriatic arthritis cases were incorporated in an open trial. Auranofin 6 mg once daily reduced significantly the activity in rheumatoid arthritis and in psoriatic arthritis. The beneficial effect obtained with auranofin at a dose of 6 mg/day during the first year of treatment could not be maintained by 3 mg/day in the second year. Auranofin compared to parenteral gold had a distinct advantage of better systemic tolerability, although parenteral gold was found to be more potent. There was no greater risk for toxic skin reaction to oral gold in psoriatic arthritis than in rheumatoid arthritis. The overall conclusion of this longterm study is that pral gold (auranofin) 6 mg once daily, although slightly less effective than parenteral gold, can be considered to be the first choice of gold treatment for rheumatoid arthritis and psoriatic arthritis, because the compliance, which is a reflection of a combination of tolerance and efficacy, for oral gold therapy was, in our hands, undoubtedly superior to parenteral gold. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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