68Ga-PSMA and 11C-Choline comparison using a tri-modality PET/CT-MRI (3.0 T) system with a dedicated shuttle
| Autor: | Margarita Garcia Fontes, Henry Engler, Omar Alonso, Henia Balter, Gerardo dos Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Biochemical recurrence PET/CT lcsh:R895-920 Biophysics urologic and male genital diseases 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Prostate cancer chemistry.chemical_compound 0302 clinical medicine Computer Science (miscellaneous) medicine Choline Radiology Nuclear Medicine and imaging In patient Pelvis PET-CT business.industry medicine.disease medicine.anatomical_structure PET/MRI chemistry Prostate Bed 030220 oncology & carcinogenesis Molecular Medicine Original Article 11C-Choline medicine.symptom 68Ga-PSMA Nuclear medicine business |
| Zdroj: | European Journal of Hybrid Imaging European Journal of Hybrid Imaging, Vol 2, Iss 1, Pp 1-16 (2018) |
| ISSN: | 2510-3636 |
| Popis: | Background The aim of this study was to prospectively compare the detection rate of 68Ga-PSMA versus 11C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality PET/CT-MRI system. Methods We analysed 36 patients who underwent both 11C-Choline PET/CT and 68Ga-PSMA PET/CT scanning within a time window of 1-2 weeks. Additionally, for the 68Ga-PSMA scan, we used a PET/CT-MRI (3.0 T) system with a dedicated shuttle, acquiring MRI images of the pelvis. Results Both scans were positive in 18 patients (50%) and negative in 8 patients (22%). Nine patients were positive with 68Ga-PSMA alone (25%) and one with 11C-Choline only (3%). The median detected lesion per patient was 2 for 68Ga-PSMA (range 0-93) and 1 for 11C-Choline (range 0-57). Tumour to background ratios in all concordant lesions (n = 96) were higher for 68Ga-PSMA than for 11C-Choline (110.3 ± 107.8 and 27.5 ± 17.1, mean ± S.D., for each tracer, respectively P = 0.0001). The number of detected lesions per patient was higher for 11C-Choline in those with PSA ≥ 3.3 ng/mL, while the number of detected lesions was independent of PSA levels for 68Ga-PSMA using the same PSA cut-off value. Metastatic pelvic lesions were found in 25 patients (69%) with 68Ga-PSMA PET/CT, in 18 (50%) with 11C-Choline PET/CT and in 21 (58%) with MRI (3.0 T). MRI was very useful in detecting recurrence in cases classified as indeterminate by means of PET/CT alone at prostate bed. Conclusions In patients with prostate cancer with biochemical recurrence 68Ga-PSMA detected more lesions per patient than 11C-Choline, regardless of PSA levels. PET/CT-MRI (3.0 T) system is a feasible imaging modality that potentially adds useful relevant information with increased accuracy of diagnosis. |
| Databáze: | OpenAIRE |
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