Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis

Autor:	Cody M. Orahoske, Marjia Afrin, Yaxin Li, Jovana Hanna, Myah Marbury, Bibo Li, Bin Su
Rok vydání:	2022
Předmět:	Proteomics Infectious Diseases Trypanosomiasis African Flagella Animals Humans Prazosin Trypanocidal Agents
Zdroj:	ACS infectious diseases. 8(8)
ISSN:	2373-8227
Popis:	Human African trypanosomiasis (HAT) remains a health threat to sub-Saharan Africa. The current treatments suffer from drug resistance and life-threatening side effects, making drug discovery for HAT still important. A high-throughput screening of the library of pharmaceutically active compounds identified prazosin, an α-adrenoceptor antagonist, that showed selective activity toward
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a104c08c66f4efaa57743f2ad88aae https://pubmed.ncbi.nlm.nih.gov/35894227 Zobrazit plný text záznamu