Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study
| Autor: | Elizabeth Barrett-Connor, Jaclyn Bergstrom, Donna Kritz-Silverstein, Linda K. McEvoy, Gail A. Laughlin, Simerjot K. Jassal, Emilie T. Reas |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cognitive aging medicine.medical_specialty Pediatrics Longitudinal study Population Comorbidity California Article 03 medical and health sciences Cognition 0302 clinical medicine Epidemiology Prevalence Vitamin D and neurology Humans Medicine Longitudinal Studies 030212 general & internal medicine Vitamin D Cognitive decline education Aged education.field_of_study business.industry General Neuroscience General Medicine Mental Status and Dementia Tests Vitamin D Deficiency Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Logistic Models Female Causal link Independent Living Geriatrics and Gerontology business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Alzheimer's Disease. 58:871-883 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-161295 |
| Popis: | BACKGROUND Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. METHODS A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were followed for up to three additional cognitive function assessments over a 12-year period. RESULTS Overall, 14% (n = 145) of participants had VitD insufficiency defined as 25OHD |
| Databáze: | OpenAIRE |
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