Relation between serum hepatitis C virus-RNA levels and efficacy of interferon-β therapy
| Autor: | Kouzou Kanki, Natsuki Nakajima, Yutaka Minohara, Yutaka Arimoto, Fumie Goshima, Hiroaki Ishiko, Toshiro Goshima, Tatsuo Kato, Hilohumi Kaku |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adolescent
business.industry Hepatitis C virus Hepacivirus Interferon-beta Hepatitis C medicine.disease_cause medicine.disease Antiviral Agents Chronic hepatitis Interferon β Interferon Hepatitis C virus RNA Chronic Disease Pediatrics Perinatology and Child Health Immunology medicine Humans RNA Viral Female Alanine aminotransferase business Complete response medicine.drug |
| Zdroj: | Pediatrics International. 37:530-533 |
| ISSN: | 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1995.tb03370.x |
| Popis: | We performed two courses of interferon-beta (IFN-beta) to a child with chronic hepatitis C. A complete response was not obtained by the first interferon treatment, however, the results of the second treatment differed from those of the first. Hepatitis C virus (HCV)-RNA remained negative and both aspartate aminotransferase and alanine aminotransferase levels remained normal after completion of the second course. From these results we estimated that HCV-RNA levels before IFN therapy could be significantly associated with the efficacy of this treatment. The serum level of HCV-RNA was 10(6) copies/50 microL before the first treatment, but was 10(3) copies/50 microL before the second course. We conclude that IFN therapy to children with hepatitis C should always be directed at providing a cure. Even if the clinical effects of the first course are minimal decreasing quantities of HCV-RNA still offer hope for cure by subsequent readministration. |
| Databáze: | OpenAIRE |
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