Evaluation of 99Tcm mercaptoacetyltriglycine for the detection and localization of gastrointestinal bleeding in an experimental animal model
| Autor: | Ibrahim Al-Wafai, Samy Sadek, Azu Owunwanne, Tagreed Yakoub, Sorren Vallgren, M. Awdeh, Hussein M. Abdel-Dayem |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal bleeding Time Factors chemistry.chemical_element Technetium Gastroenterology Technetium Tc 99m Mertiatide Internal medicine Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging Radionuclide imaging Radionuclide Imaging Gastrointestinal tract Sheep business.industry Stomach General Medicine medicine.disease Disease Models Animal Experimental animal medicine.anatomical_structure chemistry Drug Evaluation Abdomen Radiology Gastrointestinal Hemorrhage business Oligopeptides |
| Zdroj: | Nuclear Medicine Communications. 9:369-372 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-198805000-00008 |
| Popis: | Technetium-99m mercaptoacetyltriglycine (99Tcm-MAG3) was evaluated for the detection and localization of the site of gastrointestinal bleeding in a sheep model. Radioactivity was detected in both the stomach and lower abdomen. However, 99Tcm-MAG3 is partially excreted by the liver and in the bile. The radioactivity in the bile moved to the small bowel. This movement of radioactivity in the lower abdomen can lead to a misinterpretation of the site of bleeding. Hence, 99Tcm-MAG3 may not be an effective radiopharmaceutical for the localization of the site of bleeding in the gastrointestinal tract, particularly the lower abdomen. |
| Databáze: | OpenAIRE |
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