A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats
| Autor: | Catia Lambertucci, Maria Vittoria Micioni Di Bonaventura, Maurizio Massi, Rosaria Volpini, Gloria Cristalli, Carlo Cifani |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Food intake Adenosine Adenosine A2 Receptor Agonists Receptor Adenosine A2A Nerve Tissue Proteins Satiety Response Rats Sprague-Dawley Food Preferences chemistry.chemical_compound Internal medicine Appetite Depressants Phenethylamines medicine Animals Palatability CGS-21680 Pharmacology Thionucleosides Behavior Animal Dose-Response Relationship Drug Binge eating Appetite Regulation business.industry digestive oral and skin physiology Feeding Behavior Adenosine receptor Rats Disease Models Animal Psychiatry and Mental health Endocrinology chemistry Drug Therapy Combination Female medicine.symptom Energy Intake business Binge-Eating Disorder |
| Zdroj: | Behavioural Pharmacology. 23:567-574 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/fbp.0b013e3283566a60 |
| Popis: | The present study examined the effect of two A(2A) adenosine receptor (AR) agonists, CGS 21680 and VT 7, on high-palatability food (HPF) intake in a model of binge eating in sated rats and on low-palatability food (LPF) intake in food-deprived rats. Binge eating was induced in female rats by three 8-day cycles of food restriction/refeeding, followed by acute stress. Two groups of rats were used: NR+NS rats normally fed and not stressed and R+S rats exposed to cycles of food restriction/refeeding and then stressed. R+S rats had higher intake of HPF than the NR+NS controls. The two A(2A)AR agonists were tested at doses of 0.1 and 0.05 mg/kg intraperitoneally; VT 7 did not modify locomotor activity at either dose, whereas CGS 21680 only slightly reduced it at the higher dose tested. The injection of 0.1 mg/kg of both agonists markedly reduced HPF intake both in R+S and in NR+NS rats. The dose of 0.05 mg/kg was inactive. CGS 21680 and VT 7, 0.1 mg/kg, also reduced the standard LPF intake in 24 h food-deprived rats; however, they did not reduce water intake, indicating that their effect on food intake is selective. The dose of 0.05 mg/kg was inactive. Thus, A(2A)AR agonists exert a rather general effect on food intake, inhibiting both HPF intake in sated rats and LPF intake in food-deprived rats. They may potentially be useful pharmacological agents to control binge-related eating disorders and to reduce food overconsumption associated with obesity. |
| Databáze: | OpenAIRE |
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