Dopaminergic deficit is not the rule in orthostatic tremor
| Autor: | Emmanuelle Apartis, Jean Marc Trocello, Jean Yves Devaux, Marie-Odile Habert, Marie Vidailhet, Paolo Zanotti-Fregonara, André Pierre Legrand, Emmanuel Roze |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Dopamine Neurological examination Neurological disorder Central nervous system disease Degenerative disease Internal medicine Spect imaging Tremor medicine Humans Aged Tomography Emission-Computed Single-Photon Denervation Brain Mapping medicine.diagnostic_test Electromyography Dopaminergic Middle Aged medicine.disease Endocrinology Neurology Cardiology Female Neurology (clinical) Psychology Tropanes |
| Zdroj: | Movement Disorders. 23:1733-1738 |
| ISSN: | 1531-8257 0885-3185 |
| DOI: | 10.1002/mds.22224 |
| Popis: | Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age-matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with (123)I-FP-CIT SPECT imaging. There was no significant difference in (123)I-FP-CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with (123)I-FP-CIT SPECT abnormalities, as 8 of our patients had more than a 10-year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high-frequency OT. A new role may emerge for (123)I-FP-CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD. (c) 2008 Movement Disorder Society. |
| Databáze: | OpenAIRE |
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