Ascertaining baseline levels of antiretroviral therapy adherence in Uganda: a multimethod approach
Autor: | Setor K Kunutsor, Elly Katabira, John Walley, Simon Muchuro, Hudson Balidawa, Eric Ikoona, Janine Thoulass, James N Newell, Morgan V. Evans, Elizabeth Namagala |
---|---|
Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Adolescent Anti-HIV Agents HIV Infections Medication Adherence Young Adult Pharmacotherapy Acquired immunodeficiency syndrome (AIDS) Internal medicine Surveys and Questionnaires medicine Confidence Intervals Odds Ratio Humans Pharmacology (medical) Uganda Prospective Studies Young adult Sida Prospective cohort study biology business.industry Age Factors Odds ratio Middle Aged biology.organism_classification medicine.disease Confidence interval Infectious Diseases Immunology Multivariate Analysis Linear Models Female business |
Zdroj: | Journal of acquired immune deficiency syndromes (1999). 55(2) |
ISSN: | 1944-7884 |
Popis: | Background Many antiretroviral treatment (ART) adherence measurement methods have been employed by different studies, but no single method has been found to be appropriate for all settings. This study aimed to determine baseline levels of adherence using 2 measures of adherence. Methods Levels of adherence in 967 patients continuing to receive ART in 4 health facilities were assessed over a 28-week period using a clinic-based pill count method and a patient self-report questionnaire. Factors associated with adherence were also determined. Results Mean adherence (95% confidence interval) was 97.3% (96.8% to 97.9%) and 98.4% (97.9% to 98.8%) for the clinic-based pill count and patient self-report methods, respectively. Proportion of clients achieving optimal adherence (≥ 95%) was 89.9% by pill count and 94.2% by self-report. The 2 adherence measures were closely correlated with each other (r = 0.87, P = 0.000). Adherence increased with age (P = 0.014) with patients aged 40 years and below being less likely to achieve optimal adherence [odds ratio = 0.55; 95% confidence interval (0.34 to 0.89)]. Conclusions There is a very high level of optimal adherence among patients still on treatment. The combined use of these 2 replicable and reliable methods of measuring adherence is vital to ART programs in resource-constrained settings. |
Databáze: | OpenAIRE |
Externí odkaz: |