Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus
| Autor: | Ali Tariq, Scott Akers, Mayank Sardana, Julio A. Chirinos, Cees Vermeer, Maheshwara Reddy Koppula, Uzma Kewan, Melissa Beraun, Izzah Vasim, Amer Ahmed Syed, Nadja E.A. Drummen, Swapna Varakantam |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Mean arterial pressure medicine.medical_specialty Adolescent Enzyme-Linked Immunosorbent Assay Type 2 diabetes Pulse Wave Analysis 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Internal medicine Diabetes mellitus Matrix gla protein Internal Medicine medicine Humans Vascular Calcification Pulse wave velocity Aged Aged 80 and over Extracellular Matrix Proteins biology business.industry Incidence Calcium-Binding Proteins Type 2 Diabetes Mellitus Middle Aged medicine.disease United States Cross-Sectional Studies 030104 developmental biology Endocrinology Blood pressure Diabetes Mellitus Type 2 Arterial stiffness biology.protein Female business Biomarkers |
| Zdroj: | American Journal of Hypertension. 30:196-201 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpw146 |
| Popis: | BACKGROUND Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) is an inhibitor of vascular calcification. Activation of MGP is vitamin K dependent. We hypothesized that levels of inactive MGP (dephospho-uncarboxylated MGP; dp-ucMGP) are related to arterial stiffness in type 2 diabetes. METHODS We enrolled a multiethnic cohort of 66 participants with type 2 diabetes. Carotid-femoral pulse wave velocity (CF-PWV) was measured with high-fidelity arterial tonometry (Sphygmocor Device). Dp-ucMGP was measured with ELISA (VitaK; The Netherlands). RESULTS The majority of the participants were middle-aged (62 ± 12 years), male (91%), and had a history of hypertension (82%). Average hemoglobin A1C was 7.2% (55 mmol/mol). Mean dp-ucMGP was 624 ± 638 pmol/l and mean CF-PWV was 11 ± 4 m/sec. In multivariable analyses, dp-ucMGP was independently related to African American ethnicity (β = -0.24, P = 0.005), warfarin use (β = 0.56, P < 0.001), and estimated glomerular filtration rate (eGFR, β = -0.32, P < 0.001). Dp-ucMGP predicted CF-PWV (β = 0.40, P = 0.011), even after adjustment for age, gender, ethnicity, mean arterial pressure, eGFR, and warfarin use. CONCLUSIONS In our cross-sectional analysis, circulating dp-ucMGP was independently associated with CF-PWV in type 2 diabetes. This suggests that deficient vitamin K-dependent activation of MGP may lead to large artery stiffening and could be targeted with vitamin K supplementation in the patients with diabetes. |
| Databáze: | OpenAIRE |
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